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GNF-179 Metabolite
a single oral administration of Navoximod reduces the concentration of plasma and tissue Kyn by ~50%
Cells treated with BCI-121 shows a dose-dependent relationship between SMYD3 impairment and both inhibition of proliferation and reduction of targeted methyl marks (H4K5me and H3K4me2)
InChiKey: GHMLBKRAJCXXBS-UHFFFAOYSA-N
J Gerontol A Biol Sci Med Sci
AM-2099 roxytryptophan GNF-179 MetaboliteAM 2099 is a potent and selective inhibitor of voltage gated sodium channel Nav1. 7 with an IC50 of 0. 16 M for human Nav1. 7. Product information CAS Number: 1443373 17 8 Molecular Weight: 466. 46 Formula: C19H13F3N4O3S2 Chemical Name: 4 [2 methoxy 4 (trifluoromethyl)phenyl] N (1,3 thiazol 2 yl)quinazoline 7 sulfonamide Smiles: COC1=CC(=CC=C1C1=NC=NC2=CC(=CC=C21)S(=O)(=O)NC1=NC=CS1)C(F)(F)F InChiKey: VSUDRCZPHWUXEW UHFFFAOYSA N InChi: InChI=1S