OSMI-1 NH-C5-NH2 hydrochloride Genetic and pharmacological disruption of

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

Smiles: CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O

InChi: InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5

the identification of PKC412-resistant leukemic blast cells in the bone marrow of AML patients has propelled the development of novel and structurally distinct FLT3 inhibitors that have the potential to override drug resistance and more efficiently prevent disease progression or recurrence

6 nM (Human PKCθ)

OSMI-1 NH-C5-NH2 hydrochloride Genetic and pharmacological disruption ofOSMI 1 is a cell permeable O GlcNAc transferase (OGT) inhibitor with an IC50 value of 2. 7 M. OSMI 1 inhibits protein O linked N acetylglucosamine (O GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N or O linked glycans. Product information CAS Number: 1681056 61 0 Molecular Weight: 563. 64 Formula: C28H25N3O6S2 Chemical Name: (2R) N [(furan 2 yl)methyl] 2 (2 methoxyphenyl) 2 (2 oxo 1,2 dihydroquinoline 6